The Clinical Experience
Dr. Clarke performs primary and revision hip and knee replacement surgery. Dr Clarke also has a particular interest in hip resurfacing and has one of the longest and largest experiences of this procedure in the entire USA.
Licensure
State of New York
State of North Carolina
State of Iowa
Board Certified by the Royal College of Surgeons in Orthopaedic Surgery, England 2002
Fellow of the Royal College of Surgeons in Trauma and Orthopaedic Surgery
Honors and Awards
Medical Futures Innovation Award
Cambridge University orthopaedic research prize
British Orthopaedic Association Traveling Fellow
Orthopaedic trainees national research prize
International orthopaedic trainees research prize
Central England Orthopaedic Club prize
The East Midlands orthopaedic research prize
The Radcliffe Infirmary prize for medical studies
Professional Society Memberships
Orthopaedic Research Society
American Academy Orthopaedic Surgeons
Arthritis Foundation
International Society for Technology in Arthroplasty
Institution of Mechanical Engineers
British Hip Society
British Orthopaedic Research Society
British Orthopaedic Association
Publications
National and International Presentations
Random gaps explain early motion of cemented femoral hip components. Presented at the Orthopaedic Research Society, March 2006
Presidential guest lecture: Molecular Diagnosis of infection after TKR. Presented at The Brazilian International Arthroplasty Conference, June 2005
Presidential guest lecture: Metal ions after hip arthroplasty. Presented at The Brazilian International Arthroplasty Conference, June 2005
Presidential guest lecture: Hip resurfacing: past and present. Presented at The Brazilian International Arthroplasty Conference, June 2005
Serum metal ion levels after Cormet and Birmingham MOM Resurfacing Hip Arthroplasty. Presented at the American Academy of Orthopaedic Surgeons, March 2005
Metal ion levels after small and large diameter metal on metal bearings. Presented at the American Academy of Orthopaedic Surgeons, March 2004
Metal ion levels after unilateral and bilateral total hip arthroplasty. Presented at the American Academy of Orthopaedic Surgeons, March 2004
Simulated separation of hip bearing surfaces during the gait cycle. Presented at the International Society for Technology in Arthroplasty, October 2003
Metal ion levels after small and large diameter metal on metal bearings. Presented at the International Society for Technology in Arthroplasty, October 2003
Metal ion levels after unilateral and bilateral total hip arthroplasty. Presented at the International Society for Technology in Arthroplasty, October 2003
In vitro simulation of micro-separation of metal-on-metal and metal-on-polyethylene bearings during the normal gait cycle. Presented at the European Orthopaedic Research Society, June 2003
Molecular biology diagnosis of infected total hip replacement. Presented at EFORT, June 2003
Serum cobalt and chromium levels after small and large diameter metal-on-metal hip arthroplasty. Presented at EFORT, June 2003
Serum cobalt and chromium levels in patients with bilateral versus unilateral metal-on-metal total hip replacement. Presented at EFORT, June 2003
Chondro-protection with synthetic lubricants. Presented at the British Orthopaedic Research Society, April 2003.
Complications in one thousand hip arthroscopies. Presented at the International Society for Knee Surgery, Arthroscopy and Orthopaedic Sports Medicine, March 2003.
The 'suction fit' of metal-on-metal total hip replacement bearings. Presented at the British Orthopaedic Research Society, September 2002.
The protective role of metal-on-metal bearings against dislocation in THR. Presented at the International Society for Technology in Arthroplasty, September 2002.
Protective effects of synthetic lubrication in a guinea-pig model of osteoarthritis. Presented at the European Orthopaedic Research Society, October 2002.
Metal-on-metal bearing protects from dislocation after THR. Presented at the European Orthopaedic Research Society, October 2002.
Hip arthroscopy: the first one thousand cases. Presented at the European Society for Surgery to the Knee and Arthroscopy, February 2002.
Femoral neck osteoblasts, an altered rate of osteocytic incorporation: implications for bone formation. Presented at the British Society of Rheumatology, April 2002.
Determinants of osteocyte differentiation: association of coxarthrosis with reduced osteocyte lacunar density as well as increased wall width and cancellous bone area in the femoral neck. Presented at the 9th Congress of the International Society of Bone Morphometry, April 2002.
A mechanism for the increased cancellous bone in coxarthrosis: implications for the treatment of osteoporosis. Presented at the 8th Conference on Osteoporosis, November 2001.
Problems associated with the mechanical testing of retrieved PMMA. Presented at the Advanced Exeter Hip Course, November 2001.
The use of PCR in the diagnosis of infected hip replacements. Presented at the British Orthopaedic Association, September 2001.
Sub-clinical infection and 'aseptic' loosening in hip replacements. Presented at the British Hip Society Meeting, March 2001.
Clinical effectiveness of PCR in detecting prosthetic infection for revision THR. Presented at the Royal Society of Medicine, February 2001.
Tourniquet induced wound hypoxia after TKR. Presented at the British Orthopaedic Association Meeting, September 1998.
Preventing wound hypoxia after knee arthroplasty. Presented at the International Orthopaedic Residents Conference, August 1998.
Risk factors for wound hypoxia after TKR. Presented at the Central England Orthopaedic Club Meeting, April 1998.
DVT risks and total joint arthroplasty. Presented at the East Anglian Orthopaedic Meeting, Nov 1997.
Cement as a risk factor for DVT after total joint arthroplasty. Presented at the British Orthopaedic Association meeting, April 1996.
Re-admission rate for thrombo-embolic disease after THR and TKR. Presented at the British Orthopaedic Association meeting, April 1996.
NSAID induced differentiation of bone marrow derived stromal cells. Presented at The British Orthopaedic Research Society Meeting, Dundee 1995.
Current prevalence of DVT in primary knee and hip replacements without the use of routine mechanical or chemical prophylaxis. Presented at The Royal Society of Medicine and British Orthopaedic Association Joint Meeting on Thrombo-embolic Disease, London 1995.
Bone Marrow Derived Cell Populations. Presented at The World Congress on Endometriosis Conference, Brussels 1992.
GABA-like Immunoreactivity in the Turtle Cerebellum. Presented at The Annual Neuroscience Conference, Denver 1989.
Publications and Book Chapters
Mann K.A., Miller M.A., Race A.., Clarke M.T. Stem-Cement Porosity May Explain Early Loosening of Cemented Femoral Hip Components: An Experimental-Computational In Vitro Study. In press J Orthop Res 2006.
Clarke M.T. Metals and metallic alloys in Essentials of Orthopedic Surgery: Oncology and Basic Science (In Press).
Mann K.A., Miller M.A., Higham P., Race A., Clarke M.T. The Role of Cement Viscosity on Cement-Bone Apposition and Strength: An In Vitro Model with Medullary Bleeding. In press J arthroplasty 2006.
Mann K.A., Damron L.A., Blake D., Miller M.A., Race A., Clarke M.T. Random Gaps Explain Early Motion Of Cemented Femoral Hip Components. Transactions ORS 2006;31:183.
Race A., Miller M.A., Clarke, M.T., Mann K.A. The effect of low viscosity cement on mantle morphology and femoral stem micro-motion: a cadaver model with simulated blood flow. Acta Orthop Scand 2006;77(4):607-16
Race, A., Miller, M.A., Clarke, M.T., Mann, K.A. Cement/implant interface gaps explain the poor results of CMW3 for femoral stem fixation: a cadaver study of migration, fatigue and mantle morphology. Acta Orthop Scand 2005, 76(5):679-687.
Clarke M.T., Stewart T., Darrah D., Ingham I., Fisher J., Nolan J.F. Long-term clinical, radiological and histopathological follow-up of a well-fixed McKee-Farrar metal-on-metal total hip arthroplasty. Arthroplasty 2005 Jun;20(4):542-6.
Patel N., Brooks R.A., Clarke M.T., Lee PM, Rushton N., Gibson I.R., Best S.M., Bonfield W. In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model. J Mater Sci Mater Med. 2005 May;16(5):429-40.
Lee P.T.H., Clarke M.T., Bearcroft P., Robinson A.H.N.R. The proximal extent of the ankle capsule and safety for the insertion of percutaneous fine wires. J Bone Joint Surg Br. 2005. May;87(5):668-671
Clarke M.T., Lee P.T.H., Roberts C.P., Gray J., Keene G.S. and Rushton N. Contamination of primary total hip replacements in standard and ultra-clean operating theaters detected by the polymerase chain reaction. Acta Orthop Scand. 2004 Oct;75(5):544-8.
Clarke M.T., Lee P.T.H., Roberts C.P., Gray J., Keene G.S. and Rushton N. Polymerase chain reaction can detect bacterial DNA in aseptically loose total hip arthroplasties.. Clin Orthop. 2004 Oct;(427):132-7.
Clarke M.T., Lee P.T. and Villar R.N. Metal-on-metal bearing protects from dislocation after total hip replacement: a clinical and laboratory study. J Bone Joint Surg Br. 2003 Jul;85(5):650-4.
Clarke M.T., Lee P.T., Arora A., Villar R.N. Levels of metal ions after small- and large-diameter metal-on-metal hiparthroplasty. J Bone Joint Surg Br. 2003 Aug;85(6):913-7.
Jordan G.R., Loveridge N, Power JD, Clarke M.T. and Reeve J. A mechanism for the increased cancellous bone in coxarthrosis: implications for the treatment of osteoporosis. Osteoporosis International 2003;14:160-165.
Jordan G.R., Loveridge N, Power JD, Clarke M.T. and Reeve J. Femoral neck osteoblasts: an altered rate of osteocytic incorporation: implications for bone formation. Calcif Tissue Int 2003;72(3):190-6.
Jordan G.R., Loveridge N., Bell K.L., Power J., Dickson G. R., Vedi S., Rushton N., Clarke M.T. and Reeve J. Increased Cancellous Bone and Connectivity in Coxarthrosis. Bone 2003;32:86-95.
Clarke M.T., Arora A. and Villar R.N. Hip arthroscopy: complications in 1054 cases. Clin Orthop Rel Res 2003;406:84-8.
Conn K, Clarke M.T. and Hallett J.P. A simple method determining X-ray magnification and its application to pre-operative templating. J Bone Joint Surg (Br) 2002 Mar;84(2):269-72.
Clarke M.T., Longstaff L, Edwards D and Rushton N.R. Tourniquet induced hypoxia after total knee replacement. J Bone Joint Surg (Br) 2001;83:40-4.
Clarke M.T., Lyall H.A., Grant J and Matthewson M.H. The histopathology of De-Quervain's disease. J Hand Surg (Br) 1998;23B:732-734.
Clarke M.T., Green J.S., Harper W.M. and Gregg P.J. Cement as a risk factor for DVT after total hip and knee replacement. J Bone Joint Surg (Br) 1998;80B:611-613.
Clarke M.T., Green J.S., Harper W.M. and Gregg P.J. Screening for DVT after hip and knee replacement without prophylaxis. J Bone Joint Surg (Br) 1997;79B:787-791.
Fernandez-Shaw S, Clarke M.T., Hicks B, Naish C.E., Barlow D.M. and Starkey P.M. Bone marrow derived cell populations in uterine and ectopic endometrium. Human Reproduction 1995;10(9):2285-2289.
Davies R. J. O., Crosby J, Vardi-Visy K., Clarke M.T. and Stradling J. R. Non-invasive beat-to-beat ABP during non-REM sleep in obstructive sleep apnoea. Thorax 1994;49(4):335-339.
Davies R. J. O., Vardi-Visy K., Clarke M.T. and Stradling J. R. The Identification of Sleep Disordered Breathing From the Systolic Blood Pressure Profile. Thorax 1993;48:1242-1247.
Davies R. J. O., Vardi-Visy K., Clarke M. T. and Stradling J. R. Night-time Blood Pressure in Obstructive Sleep Apnoea, Snoring and Normal Sleep. Thorax 1992;47(3):216P.
Warley A., Clarke M. T., Phillips T. and Stradling J. R. Ventilatory response to an inhaled constant CO2 load and added dead space in healthy men, awake and asleep. Respiration Physiology 1989;75:183-192.
